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Tuesday, July 15, 2008

Excavated Jericho bones may help Israeli-Palestinian-German team combat tuberculosis

Six-thousand year old bones excavated in Jericho may help a joint Israeli-Palestinian-German research group combat tuberculosis.

According to Prof. Mark Spigelman of the Kuvin Center for the Study of Infectious and Tropical Diseases at the Hebrew University of Jerusalem, who is leading the Israeli team, the bones, which were all excavated by Dr. Kathleen Kenyon between fifty and seventy years ago, will be tested for tuberculosis, leprosy, leishmania and malaria. However, the primary focus will be tuberculosis.

Spigelman is known for his pioneering studies of ancient diseases (palaeoepidemiology) found on mummified bodies and human remains from Hungary and Korea to Sudan, in his quest to provide answers to the development of diseases affecting us today, such as tuberculosis, hepatitis and malaria.

'TB still the biggest killer'

Tuberculosis - or TB - is a deadly infectious bacterial disease that usually attacks the lungs. Acknowledged as a disease of crowds, it is transmitted from human to human living in close contact.

Dating back thousands of years, tuberculosis was well known in antiquity. However, according to Spigelman, it is still the biggest killer even today. One-third of the world's current population has been infected by tuberculosis, resulting, in recent years, in approximately three million deaths per year.

Why Jericho?

While the origins of tuberculosis and its evolution remain unclear, it is thought it came from the first villages and small towns in the Fertile Crescent region about 9-10,000 years ago. Jericho is one of the earliest towns on earth, dating back to 9,000 B.C., and so a lot of communicable - or town - diseases would have had a good start in this community.

By examining human and animal bones from this site, the researchers will be able to see how the first people living in a crowded situation developed the diseases of crowds and how this affected the disease through changes in DNA – of both the microbes and the people.

The most significant results of this research will come from a comparison between those data for humans and corresponding animal remains which may allow the identification of animal-human vectors and their interaction.

How can this research help us today?

Preliminary work suggests that there is sufficient DNA in the bone samples to make a contribution to our understanding of the origin and development of microbial disease which could provide crucial information in the evolution of tuberculosis.

Spigelman believes that knowing how a disease developed 6,000 years ago helps us understand what it will do as it continues to evolve, and will ultimately alter the practice of public health officials in combating it.

Where were the bones until now?

Spigelman came across the long-forgotten bones while examining mummies at Sydney University's Nicholson Museum.

"They told me they had lots of boxes of bones and didn't know what they were because they'd been deposited there fifty years earlier by an anthropologist who'd worked with Dr. Kathleen Kenyon who'd been excavating at Jericho. When I examined them, I recognized that these were the bones from Jericho, and I told them not throw them out!"

Some of the bones, which were then brought to Israel by Spigelman while on a Sir Zelman Cowan Fund fellowship, will be studied along with other bones from Jericho that have been contributed by the Duckworth Collection at Cambridge University who have agreed to participate in the project.

Israeli-Palestinian-German cooperation

The research, which is being sponsored by a grant from the German Science Foundation, Deutsche Forschungsgemeinschaft (DFG), will be conducted by the Hebrew University, Al Quds University and the Ludwig-Maximilians University, Munich. In Israel, Ph.D. and master's students from both Al-Quds and the Hebrew Universities will devote their time exclusively to this project.

According to Spigelman, the project will also help the Palestinians develop the technology and set up their own ancient DNA lab at Al Quds University.

This is one of eleven trilateral research projects at the Hebrew University involving Palestinian, Israeli and German cooperation.

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Tesla Roadsters now rolling off production line

Posted by Martin LaMonica

The world's hippest eco-chic status symbol--the Tesla Roadster--is finally leaving the factory.

The all-electric Tesla Roadsters, priced around $100,000, are now shipping, company president and CEO Ze'ev Drori told customers on Friday. The letter was reprinted on the company blog on Saturday.


One of the 27 Tesla Roadsters undergoing final assembly in the company's Menlo Park, Calif., outlet.

(Credit: Tesla Motors)

Drori said Tesla has "broken the logjam," beginning to manufacture Roadsters at a low volume, meaning that it will deliver about four a week. There are now about 27 Roadsters in various stages of assembly, he said.

Production, done at a Lotus plant in the United Kingdom, will remain low until September, when the company starts to incorporate its second drivetrain, Powertrain 1.5, designed to give the car better performance.

In December, the goal is to produce 100 Roadsters a week.

It's a dose of good news for Tesla's well-heeled customers, who have had to endure months of delays.

Tesla has had both technological challenges in making an all-electric car that runs on lithium-ion batteries, as well as a management turmoil, detailed in great detail in this recent Fortune report.

Click on the image to see a photo gallery of the first Roadsters in production.

(Credit: Corinne Schulz/CNET Networks)

Tesla's largest investor, PayPal founder Elon Musk, took over control of the company last year and ousted founder Martin Eberhard as the carmaker transitioned from technological development to product shipping.

Tesla also recently named former Chrysler executive Mike Donoughe as executive vice president of vehicle engineering and manufacturing.

Tesla is, perhaps, the most high-profile green-tech company to emerge from a swell of activity in the past four years. Its problems illustrate some of the challenges in energy technology start-ups.

Unlike start-ups trying to sell to, say, electric utilities, Tesla's wealthy, techno-savvy clients are willing to shoulder some of the risk of a new product.

Drori also announced in the company blog that Tesla has opened its second store in Menlo Park, Calif., replicating the high-touch sales environment of its first store in Los Angeles. Showrooms in New York, Chicago, Miami, and Seattle are planned as well.

The Roaster will have a range of 220 miles per charge and the mileage equivalent of 135 mpg. It can go from standing still to 60 mph in less than 4 seconds.

The company is also planning to make an all-electric sedan priced at about $60,000.

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Turning over the keys to the car ... to the car

Why leave all the fun to David Hasslehoff when you could have your very own K.I.T.T. in the next couple of decades or so?

By David Kiley

Imagine the scene: You're driving your car to an office building in New York City, five minutes from a job interview. No worries. You have already dialed into the car's memory the parking garage where it's going to stay, and prepaid the bill. You shut the door. And off it goes. Driverless. And the chances of the car getting into an accident while it travels five or six treacherous city blocks are less than if the hopeful job applicant had tried to park it himself under time pressure.

Does it sound too good to be true? A sign of the end of civilization as we know it? Too far into the future to care? It depends on whom you ask. But some researchers, engineers, and auto companies believe that such automation is not only on the way to becoming commonplace in the next 20 years, but essential to reducing the carbon footprint of vehicles from the U.S. to China and everywhere else. Oh, and as the technology necessary to achieve the "autonomous" car arrives in stages every few years — some of it is already here, in options such as electronic stability control and blind-spot detection — it promises to sharply reduce traffic fatalities.

'Better than humans'
That's why Nady Boules is so enthusiastic about the prospects of putting technology into vehicles that will change the way we drive and even think about personal transportation. He is director of General Motors' electrical and integration laboratory, and thus is at the center of the automaker's research into what technology is possible and how well consumers might embrace it. "All of this will be made possible and practical by use of computers, sensors, and radio transmitters, and I think we are coming to realize that they can operate a vehicle or even a plane better than humans can behind the wheel," says Boules.

For now, GM can claim bragging rights among automakers for advancing autonomous driving. Last November, a Chevy Tahoe nicknamed "Boss," engineered by a team drawn from GM, Continental Teves, Caterpillar, and Carnegie-Mellon University, beat out 85 other teams and entries for the Defense Advanced Research Projects Agency, or DARPA, Urban Challenge. The Pentagon sponsored the competition to develop an autonomous fighting vehicle that will keep as many human war-fighters off the battlefield as possible. You have heard of "drone" fighter and intelligence-gathering planes? The DOD wants tanks and other vehicles that don't even need to be operated by remote control, let alone humans.

How do the vehicles work without even remote control? It takes a combination of technologies.

Electronic stability control: This technology, which now comes or will soon come standard in most vehicles, improves a vehicle's handling by detecting and preventing skids. When ESC detects loss of steering control, the system automatically applies individual brakes to help "steer" the vehicle where the driver wants to go. Braking is automatically applied to individual wheels, such as the outer front wheel to counter oversteer, or the inner rear wheel to counter understeer. Some ESC systems also reduce engine power until control is regained.

Adaptive cruise control: This is similar to standard cruise control in that it maintains the vehicle's preset speed. However, unlike conventional cruise control, ACC can automatically adjust speed in order to maintain a proper distance between vehicles in the same lane. This is achieved through a radar headway sensor, a digital signal processor, and a longitudinal controller. If the vehicle ahead of you slows down, or if another object is detected, the system sends a signal to the engine or braking system to decelerate. Then, when the road is clear, the system accelerates back to the set speed. GM's Cadillac models and Buick Lucerne now offer it as an option, as do Mercedes-Benz, Infiniti, and Lexus.

Blind-spot detection: This system — offered by Cadillac, Buick, Volvo, Mercedes, and other makes — watches the surroundings of the car with cameras, sensors, and radar, and lets the driver know by way of a light on the side-view mirror that a car is hovering in the blind spot.

Lane-departure warning: If the car drifts out of the lane, one system will vibrate the steering wheel, alerting the driver, who may be falling asleep. Another kind of system will also send a message to the steering wheel to steer back into the lane. This is expected to be available as early as 2011 as an option offered with other systems, such as adaptive cruise control.

Collision mitigation: This system, like one developed by Honda Motor and offered in Acura models, determines the likelihood of a collision based on driving conditions, distance to the vehicle ahead, and relative speeds. It uses visual and audio warnings to prompt the driver to take preventive action. It also initiates braking to reduce the vehicle's speed. When a collision is anticipated, the seatbelt retracts in anticipation of impact.

Each of these technologies can stand alone. But they're also designed to be added on to and integrated with one another over time, says GM's Boules. The "Boss" SUV was packed with thousands of dollars of advanced equipment and software that's not yet commercially available, such as an enhanced global positioning system, radar and sonar, and radio transmitters. On the test course it had to maneuver around vehicles driven by humans, as well as other driverless vehicles.

At a four-way stop with another autonomous vehicle, the Boss and its fellow "car-bot" communicated with one another, negotiating which would go first. "They are more polite than people," says Boules.

Price dampens consumer enthusiasm
Polite or not, people have to buy into these technologies if they're going to catch on. According to the recently completed Emerging Technologies Study, conducted each year by J.D. Power and Associates, there's a lot of interest in the individual systems that will make autonomous driving possible: 76 percent of those surveyed are interested in blind-spot detection; 74 percent want backup assist; 62 percent want a collision mitigation system; 60 percent want adaptive cruise control, and 46 percent want lane-departure warning. However, those percentages drop a bit when price tags are suggested for each system.

The $1,300 GM "Driver Awareness Package," offered on the Cadillac CTS and DTS and Buick Lucerne, includes lane-departure warning, blind-spot detection, and heads-up instrument-panel display. So far this year, 5 percent of CTS sedan buyers have opted for the package.

J.D. Power's Mike Marshall, who oversees the Power study, says drivers will need time to get used to turning more and more control of the car over to computers and sensors. "Even I held my foot over the brake for a while before I trusted adaptive cruise control to do it for me, and I know more than most about how this stuff works," says Marshall.

The bigger payoff in having drivers spend a few thousand dollars to embrace autonomous vehicles is the huge improvements they promise in safety and fuel economy. About 43,000 people a year are killed in traffic accidents, including motorcycle accidents and pedestrians hit by moving cars. If every car had electronic stability control, for instance, fatalities would drop by about 10,000, according to estimates by the Insurance Institute for Highway Safety. If all drivers wore safety belts (about 81 percent do today), another 7,000 lives would be saved.

"The number goes down with each system to the point where [fatalities] would be so few that when it happened, it would really be an oddity," says Boules.

Much lighter
How could car-bots that drive themselves be more energy efficient? Vehicles would be so safe that automakers could dramatically reduce the weight of cars and trucks by eliminating a lot of steel, bumpers, etc. Even airbags eventually could be eliminated. Much more of the vehicle could be made from plastics and other synthetics, even recycled paper and other cellulose-based material. With weight reduction comes fuel economy. A minivan that gets about 19 miles per gallon today could be made to weigh less than a Honda Fit, which gets more than 34 mpg. And the Fit could be lightened up enough to get 45 mpg or better.

Here is the kicker: Older people will have the greatest incentive to embrace the newest technology, a reversal of the usual trend with emerging technology. As baby boomers age into their 70s and 80s, living longer thanks to drugs, artificial joints, heart valves, and the like, they will want to continue driving as long as possible. The biggest beef against elderly drivers today is that their reflexes and eyesight deteriorate before their desire to drive their own cars.

With an autonomous car that can be driven safely on autopilot, it's the car's eyesight and reflexes that will matter more than the driver's.

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