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Saturday, July 19, 2008

Cops return medical-marijuana files taken in raid — but not the pot

Seattle police returned hundreds of patient files and a computer hard drive to Martin Martinez Thursday evening, two days after they raided his University District storefront where he runs a collective and outreach group for medical-marijuana patients.

Prosecutors have told Martinez he won't face any charges and the investigation is now closed.

"Nothing is going to happen. It's done," said Douglas Hiatt, Martinez's lawyer, who went to the Seattle Police Department Thursday to pick up the files and other belongings.

But police have so far refused to return about 12 ounces of marijuana and two bongs seized during Tuesday's bust, Hiatt said.

According to Hiatt, a police-department attorney has promised that the drugs and water pipes won't be destroyed until Hiatt can raise the issue with King County Prosecuting Attorney Dan Satterberg or take the matter to court.

"It's really the principle — if you have the legal right to have something, the police shouldn't be able to take it away from you and not give it back," Hiatt said.

Dan Donohoe, a spokesman for Satterberg, confirmed the files' return and that Martinez would not face criminal charges but referred questions about the seized marijuana to Seattle police, who couldn't be reached Thursday.

In a written statement, Satterberg said police "acted appropriately" and were right to seize items from Martinez because "they reasonably believed that they showed an effort to distribute marijuana in violation of state law."

But the statement also acknowledges that Martinez, who suffered severe neurological damage in a motorcycle accident in 1986, "is authorized to possess marijuana for medical purposes," and that the amount of pot seized by police was arguably within the 60-day supply limit the state medical-marijuana law provides.

Seattle police searched Martinez's office on Northeast 50th Street after neighbors complained of a strong odor of pot in the building. After obtaining a search warrant, they carted off the pot and the files, which included detailed medical histories and medical-marijuana prescriptions. They also broke down part of a wall in search of marijuana plants. They didn't find any.

Food for thought

Eat your way to a better brain

CHILDREN have a lot to contend with these days, not least a tendency for their pushy parents to force-feed them omega-3 oils at every opportunity. These are supposed to make children brainier, so they are being added to everything from bread, milk and pasta to baby formula and vitamin tablets. But omega-3 is just the tip of the nutritional iceberg; many nutrients have proven cognitive effects, and do so throughout a person’s life, not merely when he is a child.

Fernando Gómez-Pinilla, a fish-loving professor of neurosurgery and physiological science at the University of California, Los Angeles, believes that appropriate changes to a person’s diet can enhance his cognitive abilities, protect his brain from damage and counteract the effects of ageing. Dr Gómez-Pinilla has been studying the effects of food on the brain for years, and has now completed a review, just published in Nature Reviews Neuroscience, that has analysed more than 160 studies of food’s effect on the brain. Some foods, he concludes, are like pharmaceutical compounds; their effects are so profound that the mental health of entire countries may be linked to them.

Last year, for example, the Lancet published research showing that folic-acid supplements—sometimes taken by pregnant women—can help those between 50 and 70 years old ward off the cognitive decline that accompanies ageing. In a study lasting three years, Jane Durga, of Wageningen University in the Netherlands, and her colleagues found that people taking such supplements did better on measures of memory, information-processing speed and verbal fluency. That, plus evidence that folate deficiency is associated with clinical depression, suggests eating spinach, orange juice and Marmite, which are all rich in folic acid.

Another suggestion from Dr Gómez-Pinilla’s review is that people should eat more antioxidants. That idea is not new. Antioxidants are reckoned by many to protect against the general effects of ageing. Vitamin E, for example, which is found in vegetable oils, nuts and green leafy vegetables, has been linked (in mice) with the retention of memory into old age, and also with longer life.

Dr Gómez-Pinilla, however, gives the antioxidant story a particular twist. The brain, he observes, is peculiarly susceptible to oxidative damage. It consumes a lot of energy, and the reactions that release this energy also generate oxidising chemicals. Moreover, brain tissue contains a great deal of oxidisable material, particularly in the fatty membranes surrounding nerve cells.

That suggests, among other things, the value of a diet rich in berries. These have been shown to have strong antioxidant effects, though only a small number of their constituents have been evaluated in detail. One group that has been evaluated, the polyphenols, has been shown in rodents to reduce oxidative damage and to boost the ability to learn and retain memories. In particular, these chemicals affect changes in response to different types of stimulation in the hippocampus (a part of the brain that is crucial to the formation of long-term memories, and which is the region most affected by Alzheimer’s disease). Another polyphenol, curcumin, has also been shown to have protective effects. It reduces memory deficits in animals with brain damage. It may be no coincidence that in India, where a lot of curcumin is consumed (it is the substance that makes turmeric yellow), Alzheimer’s disease is rarer than elsewhere.

Peas of mind

Though the way antioxidants work in the brain is not well known, Dr Gómez-Pinilla says it is likely they protect the synaptic membranes. Synapses are the junctions between nerve cells, and their action is central to learning and memory. But they are also, he says, the most fragile parts of the brain. And many of the nutrients associated with brain function are known to affect transmission at the synapses.

An omega-3 fatty acid called docosahexaenoic acid (DHA), for example, provides membranes at synaptic regions with “fluidity”—the capacity to transport signals. It also provides “plasticity”—a synapse’s capacity to change. Such changes are the basis of memory. Since 30% of the fatty constituents of nerve-cell membranes are DHA molecules, keeping your DHA levels topped up is part of having a healthy brain. Indeed, according to the studies reviewed by Dr Gómez-Pinilla, the benefits of omega-3s include improved learning and memory, and resistance to depression and bipolar disorder, schizophrenia, dementia, attention-deficit disorder and dyslexia.

Omega-3s are found in oily fish such as salmon, as well as in walnuts and kiwi fruit, and there is a strong negative correlation between the extent to which a country consumes fish and its levels of clinical depression. On the Japanese island of Okinawa, for example, people have a strikingly low rate of mental disorder—and Okinawans are notable fish eaters, even by the standards of a piscivorous country like Japan. In contrast, many studies suggest that diets which are rich in trans- and saturated fatty acids, such as those containing a lot of deep-fried foods and butter, have bad effects on cognition. Rodents put on such diets show declines in cognitive performance within weeks.

In the past few years, several studies have looked at the effect of adding omega-3s to people’s diets—particularly those of children. One such, carried out in the British city of Durham, was controversial in that it was funded by a maker of children’s omega-3 supplements and did not include a control group being given a placebo. Despite the publicity this study has received, Ben Goldacre, author of a book called “Bad Science” that includes an investigation of it, says the results will not be released.

Work by other researchers, however, has suggested such supplements do improve the performance and behaviour of school-age children with specific diagnoses such as dyslexia, attention-deficit disorder and developmental co-ordination disorder. Moreover, although more work is needed to elucidate the effects of omega-3s on healthy school-age children, Dr Gómez-Pinilla says that younger children whose mothers took fish-oil supplements (which contain omega-3s) when they were pregnant and while they were breast-feeding do show better cognitive performance than their unsupplemented contemporaries.

Eating well, then, is one key to a healthy brain. But a word of warning—do not overeat. This puts oxidative stress on the brain and risks undoing all the good work those antioxidants have been up to. For those who would like a little practical guidance, The Economist has some suggestions for dinner (see menu). So why not put the Nintendo brain trainer away tonight, and eat your way to intelligence instead?



FDA Lifts Tomatoes Salmonella Warning

WASHINGTON — It's OK to eat all kinds of tomatoes again, the U.S. government declared Thursday _ lifting its salmonella warning on the summer favorites amid signs that the record outbreak, while not over, may finally be slowing.

Hot peppers still get a caution: The people most at risk of salmonella _ including the elderly and people with weak immune systems _ should avoid fresh jalapenos and serranos, and any dishes that may contain them such as fresh salsa, federal health officials advised.

Investigators still don't know what caused the salmonella outbreak, which now has sickened 1,220 people in 42 states _ the earliest falling ill on April 10 and the latest so far on July 4.

But Thursday's move, coming as the tomato industry estimates its losses at more than $100 million, doesn't mean that tomatoes harvested in the spring are cleared. It just means that the tomatoes in fields and stores today are safe to eat, said Dr. David Acheson, the Food and Drug Administration's food safety chief.

"This is not saying that anybody was absolved," Acheson said. But, "as of today, FDA officials believe that consumers may now enjoy all types of fresh tomatoes available without concern of becoming infected with salmonella Saintpaul," the outbreak strain.

Early on, there was good evidence linking certain raw tomatoes to the sick, Acheson stressed. Yet inspectors haven't found the outbreak strain of salmonella Saintpaul on any farms, in suspect areas of south Florida and parts of Mexico, where they've managed to trace tomatoes thought to have been eaten by patients.

As the outbreak stretched into last month, more evidence emerged against fresh jalapenos _ the FDA's hottest lead for now. The agency sent inspectors to a Mexican packing house that supplied peppers linked to a cluster of those illnesses.

Also still on the suspect list is fresh cilantro.

Separately Thursday, North Carolina officials who were investigating some salmonella Saintpaul cases linked to a Charlotte-area restaurant announced a recall of jalapenos and avacados shipped to that state from a Texas food supply company. More tests are needed to see if the salmonella found in two samples is the outbreak strain, or another variety.

There are signs that the outbreak is slowing, said Dr. Robert Tauxe of the Centers for Disease Control and Prevention. The CDC charted the dates when the ill say they fell sick. Between April and mid-May, illnesses steadily rose. Between May 20 and June 10, the outbreak hit a plateau, with about 33 people a day becoming ill. From June 11 to June 20, that dropped to 19 people a day becoming ill.

Those are the latest available statistics, because it can take two weeks or longer for the CDC to receive confirmation that someone who is sick actually has the implicated salmonella strain.

For every salmonella case the CDC confirms, it estimates there are 30 to 40 more that go undocumented, perhaps because people don't see a doctor or undergo the right testing.

How could two different types of produce be contaminated with what is a rare type of salmonella?

One possibility is that a large farm grew tomatoes in one section and peppers in another, and both went through a common washing station with contaminated water, Acheson said.

"Bear in mind this is not following the trail of a regular old produce outbreak," he said. "There's something else going on here that is a little unusual. You need to think outside the box."

The tomato industry _ which held an unprecedented meeting with FDA Commissioner Andrew von Eschenbach and other officials on Monday _ welcomed the announcement.

"We have long been confident that Florida's tomatoes were not associated with the salmonella Saintpaul outbreak," said the Florida Tomato Growers Exchange, whose farmers are deciding whether to start planting for a fall tomato harvest. "Tomatoes from Florida's growing regions have been gone from the marketplace for weeks, so they could not have been the source of the contamination."

In Monday's meeting, the industry urged FDA to share more details of its investigation so producers could offer more possibly helpful information. If the sick were more likely to fall ill from chain restaurants than mom-and-pop establishments, for instance, the industry could help point FDA toward different lines of suppliers, explained Kathy Means of the Produce Marketing Association. The FDA promised to consider the request.

Original here