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Wednesday, September 10, 2008

When Smoking Tastes Good, It's Harder to Quit

chocolate-cigarette
Seemingly safe—and yummy—cigarette additives like cocoa can have a dangerous effect when inhaled.
(GETTY IMAGES/HEALTH)
You may find yourself missing more than nicotine when you finally snub out your last butt. Cigarettes are designed to manipulate your taste buds too, and research shows that tobacco’s flavors, both natural and added, can hold extra sway for many people struggling to quit.

"The sensory components—the taste of it, the feel of inhaled smoke—these are an important part of why people smoke," says Joseph McClernon, PhD, an assistant research professor in the Department of Psychiatry and Behavioral Sciences at Duke University Medical Center.

And they are also an important part of why people quit. "Taste can potentially help us explain who smokes and who doesn’t," says McClernon.

A little chocolate with your cigarette?
A typical cigarette may include cocoa, honey, vanilla, and licorice. While the taste of a particular brand has a lot to do with its tobacco blend, hundreds of additives may be included to smooth out the tobacco’s rough edges and create a more delicious puff.

This may sound like nothing more than a tricky way of winning your loyalty to a particular brand—or to cigarettes in general. But many of these additives can be dangerous when inhaled. "The additives are found in a lot of products that are eaten and are safe, but when burned they’re different products," explains K. Michael Cummings, PhD, chair of the department of health behavior at Roswell Park Cancer Institute in Buffalo, N.Y.

Cocoa, for example, is a nice treat for a cold winter’s night when mixed in its powdered form with hot milk. But when burned in a cigarette, cocoa produces bromine gas, which both dilates and anesthetizes the lungs, maximizing their absorption of smoke and nicotine.

"Bitter tasters" are less likely to smoke
Not everyone is susceptible to the sweet lure of cigarettes’ taste. So-called bitter tasters are less likely to cite taste as a motivating factor for smoking—and less likely to smoke in the first place.

This category of smoker was investigated in a 2001 study published in Addictive Behaviors; researchers at the National Institutes of Health compared subjects’ genetic ability to recognize bitter flavors with their likelihood of smoking and their motivations for lighting up.

The study found that at the other end of the spectrum from bitter tasters were smokers with very little bitter sensitivity ("nontasters"), who were at higher risk for heavy smoking and therefore more likely to become addicted to nicotine.

Some food makes smoking taste better
If you’re not genetically programmed to find smoking hard to quit, maybe it’s the food you eat that makes cigarettes so enticing.

A 2007 study—led by McClernon and published by Duke University Medical Center in Nicotine & Tobacco Research—found that certain foods enhance smoking, while other foods get in the way of one's enjoyment of a cigarette. Red meat, coffee, and alcohol seem to make cigarettes taste better, while fruits, vegetables, dairy products, and noncaffeinated beverages such as water and juice were most often cited as interfering with the taste.

This may explain the coffee-cigarette connection as well. "The conventional wisdom has been that there’s something about the combination of nicotine and caffeine that smokers like," McClernon says, referring to theories that the two substances may complement each other chemically. "But it may simply be that they taste better together—like Oreos and cold milk."

The research is preliminary, but it does suggest a decent strategy for quitting smoking. Grabbing a celery or carrot stick might indeed do more than just distract you from your cigarette craving.
Lead writer: Claire Stanford

Original here

Why drunks forget the embarrassing things they do

By Richard Gray, Science Correspondent

Research at the University of Sussex has found that alcohol influences the brain's ability to form memories, making memories before a drink stronger and memories of things that happen while under the influence weaker.

It means that while a drinker may remember the happy events such as socialising with friends at the start of a drinking session, they are less able to recall the negative effects that happen later in the night.

Professor Theodora Duka, from the department of experimental psychology at the University of Sussex, said: "This bias towards positive memories means that people are more likely to drink heavily the next time they go out because they only remember the good memories about the last time.

"It is not exactly clear how alcohol changes the way memories are made, but it could be altering the neurotransmitters that form memories."

Professor Duka, who was speaking at the British Association for the Advancement of Science Festival, explained she had compared the ability of volunteers to recall a series of images when they had been given either an alcoholic drink or a non-alcoholic drink.

She found that alcohol increased the memory for images seen before they had a drink and impaired memory for the images seen after the administration.

They were also more likely to remember images seen before a drink if they triggered strong emotions such as joy, while less likely to remember emotional images seen after taking a drink.

Dr Matt Field, a lecturer in psychology at Liverpool University, said that heavy alcohol consumption also caused long-term changes in brain function that left young people more prone to impulsive and risky behaviour even when sober.

He said: "Heavy drinking also leaves adolescents more sensitive to alcohol cues, so they want to drink more."

Original here

Marijuana Ingredients Show Promise In Battling Superbugs


Substances in marijuana show promise for fighting deadly drug-resistant bacterial infections, including so-called "superbugs," without causing the drug's mood-altering effects, scientists in Italy and the United Kingdom are reporting. (Credit: iStockphoto/Karin Lau)

Substances in marijuana show promise for fighting deadly drug-resistant bacterial infections, including so-called "superbugs," without causing the drug's mood-altering effects, scientists in Italy and the United Kingdom are reporting.

Besides serving as infection-fighting drugs, the substances also could provide a more environmentally-friendly alternative to synthetic antibacterial substances now widely used in personal care items, including soaps and cosmetics, they say.

In the new study, Giovanni Appendino and colleagues point out that scientists have known for years that marijuana contains antibacterial substances. However, little research has been done on those ingredients, including studies on their ability to fight antibiotic resistant infections, the scientists say.

To close that gap, researchers tested five major marijuana ingredients termed cannabinoids on different strains of methicillin-resistant Staphylococcus aureus (MRSA), a "superbug" increasingly resistant to antibiotics.

All five substances showed potent germ-killing activity against these drug-resistant strains, as did some synthetic non-natural cannabinoids, they say. The scientists also showed that these substances appear to kill bacteria by different mechanisms than conventional antibiotics, making them more likely to avoid bacterial resistance, the scientists note. At least two of the substances have no known mood-altering effects, suggesting that they could be developed into marijuana-based drugs without causing a "high."

Original here